Invasive Cribriform Breast Carcinoma Detected in A Male

Authors

  • Nik Farhan Qistina Nik Mhd Abdull Nasser
  • Nasibah Mohamad
  • Juhara Haron

Keywords:

Invasive cribriform carcinoma, breast, ultrasonography, male population

Abstract

World Health Organization (WHO) has categorized invasive breast carcinoma into several subtypes. One of these includes invasive cribriform carcinoma (ICC) of breast which we will describe in our case report. ICC is a rare histological subtype of invasive breast carcinoma and it is extremely rare in male population. As far as our knowledge concerns, only few ICC cases in males have been reported in previous studies. In this case report, we will be describing the rare incidence of ICC of breast in a 66-year-old male with a pedunculated mass at the left nipple. Ultrasonography showed a non-circumscribed irregular heterogeneously hypoechoic lesion at left retro-areolar region (BI-RADS 4). On computed tomography (CT) imaging, this lesion appears as an enhancing spiculated soft tissue lesion. Histopathological examination demonstrates features of invasive cribriform carcinoma (Modified Bloom Richardson grade I). Patient was well after left mastectomy was performed.

References

[1] Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, et al. Breast Cancer- Epidemiology, Risk factors, Classification, Prognostic Markers, and Current Treatment Strategies- An Updated Review. Cancers. 2021 Aug 25;13(17):4287. Available from: https://doi.org/10.3390/cancers13174287

[2] Hassett MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, et al. Management of Male Breast Cancer: ASCO Guideline. Journal of Clinical Oncology. 2020 Feb 14;38(16):1849–63. Available from: https://doi.org/10.1200/jco.19.03120

[3] Lim HS, Jeong SJ, Lee JS, Park MH, Yoon JH, et al. Sonographic findings of invasive cribriform carcinoma of the breast. Journal of Ultrasound in Medicine. 2011 May 1;30(5):701–5. Available from: https://doi.org/10.7863/jum.2011.30.5.701

[4] Demir S, Sezgin G, Sari AA, Kucukzeybek BB, Yigit S, et al. Clinicopathological analysis of invasive cribriform carcinoma of the breast, with review of the literature. Annals of Diagnostic Pathology. 2021 Jul 24;54:151794. Available from: https://doi.org/10.1016/j.anndiagpath.2021.151794

[5] Adachi Y, Katsuki T, Sasaguri T, Hirata K, Nagata N. Invasive cribriform carcinoma of the breast detected incidentally on computed tomography: A case report. Clinical Case Reports. 2021 Dec 1;9(12). Available from: https://doi.org/10.1002/ccr3.5214

[6] Liu J, Zheng X, Han Z, Lin S, Han H, et al. Clinical characteristics and overall survival prognostic nomogram for invasive cribriform carcinoma of breast: a SEER population-based analysis. BMC Cancer. 2021 Feb 16;21(1). Available from: https://doi.org/10.1186/s12885-021-07895-5

[7] Lee YJ, Choi BB, Suh KS. Invasive cribriform carcinoma of the breast: mammographic, sonographic, MRI, and 18 F-FDG PET-CT features. Acta Radiologica. 2014 Jun 18;56(6):644–51. Available from: https://doi.org/10.1177/0284185114538425

[8] Balci P, Akin IB, Köremezli N, Durak MG, Altay C, et al. Evaluation and comparison of radiologic-pathologic findings in invasive cribriform carcinoma of the breast. Turkish Journal of Medical Sciences. 2017 Jan 1;47:738–47. Available from: https://doi.org/10.3906/sag-1508-53

[9] Staging & Grade - Breast Pathology | Johns Hopkins Pathology. Available from: https://pathology.jhu.edu/breast/staging-grade

[10] Yerushalmi R, Hayes MM, Gelmon KA. Breast carcinoma—rare types: review of the literature. Annals of Oncology. 2009 Jul 15;20(11):1763–70. Available from: https://doi.org/10.1093/annonc/mdp245

[11] Stutz JA, Evans AJ, Pinder S, Ellis IO, Yeoman LJ, et al. The radiological appearances of invasive cribriform carcinoma of the breast. Clinical Radiology. 1994 Oct 1;49(10):693–5. Available from: https://doi.org/10.1016/s0009-9260(05)82662-5

[12] Youk JH, Gweon HM, Son EJ. Shear-wave elastography in breast ultrasonography: the state of the art. Ultrasonography. 2017 Apr 4;36(4):300–9. Available from: https://doi.org/10.14366/usg.17024

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Published

2025-10-27

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Section

Journal of Biomedical and Clinical Sciences