Conjunctival Intraepithelial Neoplasm III: A Case Report
Keywords:
Bowen’s disease, conjunctival intraepithelial neoplasm, premalignantAbstract
We report a case of conjunctival intraepithelial neoplasia type III (CIN III) in a patient presenting with lesion over the conjunctival and eventually invading the cornea. A 65-years-old lady presented with a whitish lesion over her right eye for one year. She noticed the lesion arising from supero-temporal conjunctiva and growing slowly over time, covering the upper part of the cornea. Right eye examination showed her best corrected visual acuity was 6/12. There was presence of a conjunctival lesion covering the superior half of the cornea with presence of feeding vessels. Excisional biopsy for the right conjunctival lesion was performed. Histopathological examination confirmed the diagnosis of conjunctival intraepithelial neoplasia (CIN) III. In view of malignant potential, CIN must be diagnosed promptly, differentiated carefully, and treated accordingly.References
Nelson KD, McSoley JJ. Clinical findings and management of conjunctival intraepithelial neoplasia. Optometry. 2011;82(1):15-21. doi: 10.1016/j.optm.2010.05.010.
Reidy JJ, Bouchard CS, Florakis GJ, et al. Basic and Clinical Science Course, 2011-2012. 2011:226–233.
Chaidaroon W, Dejkriengkraikul C, Isipradit S, Lertprasertsuke N. Conjunctival intraepithelial neoplasia in a patient presenting with pigmented conjunctival lesion. Case Rep Ophthalmol. 2021;12(1):77-82. doi: 10.1159/000510570.
Surapaneni KR, Nehls SM, Potter HD. Conjunctival intraepithelial neoplasia. Ophthalmology. 2015;122(5):1039. doi: 10.1016/j.ophtha.2014.12.022.
Kiire CA, Dhillon B. The aetiology and associations of conjunctival intraepithelial neoplasia. Br J Ophthalmol. 2006;90(1):109-113. doi: 10.1136/bjo.2005.077305.
Thomas BJ, Galor A, Nanji AA, El Sayyad F, Wang J, Dubovy SR, Joag MG, Karp CL. Ultra high-resolution anterior segment optical coherence tomography in the diagnosis and management of ocular surface squamous neoplasia. Ocul Surf. 2014;12(1):46-58. doi: 10.1016/j.jtos.2013.11.001.
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