Breast cancer in young pregnancy: A management dilemma

Authors

  • Hwang Zhen Shan Universiti sains malaysia
  • Juhara Haron Universiti sains malaysia
  • Maya Mazwin Yahya Universiti sains malaysia
  • Wan Faiziah Wan Abdul Rahman Universiti sains malaysia
  • Tengku Ahmad Damitri Al-astani Universiti sains malaysia

Keywords:

Young pregnancy, Breast cancer, Breast cancer management

Abstract

Breast cancer in young pregnancy is a breast cancer diagnosed in a young lady at the age of less than 30 years old during pregnancy. Diagnosis and treatment of breast cancer during pregnancy are challenging as both maternal and foetal outcome must be considered in terms of their short and long-term effects. It requires multidisciplinary treatment. Instead, pregnancy should be preserved whenever possible, while treating the underlying breast cancer. It is important not to compromise the treatment of breast cancer because of the pregnancy. The overall therapeutic concept basically depends on timing of delivery, staging of the underlying disease, treatment mode and the impacts of treatment recommended as well as foetal outcome in relation to treatment that administered to the mother during pregnancy. We present a case of young pregnant lady at the age of 23 with breast cancer as it is a rare event and the challenges encounter in managing her and to highlight the treatment options for the patient and the baby.

References

Jones AL. Management of pregnancy-associated breast cancer. The breast. 2006;15:S47- S52.

Albain KS, Allred DC, Clark GM. Breast cancer outcome and predictors of outcome: are there age differentials. J Natl Cancer Inst Monogr. 1994;16(16):35-42.

Schedin P. Pregnancy-associated breast cancer and metastasis. Nat Rev Cancer. 2006;6(4):281-91.

Keyser EA, Staat BC, Fausett MB, Shields AD. Pregnancy-associated breast cancer. Rev Obstet Gynecol. 2012;5(2):94-9.

Ahn BY, Kim HH, Moon WK, Pisano ED, Kim HS, Cha ES, et al. Pregnancyâ€and lactationâ€associated breast cancer: mammographic and sonographic findings. Journal of ultrasound in medicine. 2003;22(5):491-7.

Kopans D. The altered breast: pregnancy, lactation, biopsy, mastectomy, radiation, and implants. Breast Imaging, 2nd ed Philadelphia: Lippincott-Raven. 1998:445-7.

Ring AE, Smith IE, Jones A, Shannon C, Galani E, Ellis PA. Chemotherapy for breast cancer during pregnancy: an 18-year experience from five London teaching hospitals. Journal of clinical oncology. 2005;23(18):4192-7.

Azim Jr HA. Peccatori FA Pavlidis N. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: solid tumors. Cancer Treat Rev. 2010;36:101-9.

Yu H, Cheung P, Leung R, Leung T, Kwan W. Current management of pregnancy- associated breast cancer. Hong Kong Med J. 2017;23(4):387-94.

Amant F, Vandenbroucke T, Verheecke M, Fumagalli M, Halaska MJ, Boere I, et al. Pediatric outcome after maternal cancer diagnosed during pregnancy. New England Journal of Medicine. 2015;373(19):1824-34.

Pavlidis N, Pentheroudakis G. The pregnant mother with breast cancer: diagnostic and therapeutic management. Cancer Treat Rev. 2005;31(6):439-47.

Zemlickis D, Lishner M, Degendorfer P, Panzarella T, Burke B, Sutcliffe SB, et al. Maternal and fetal outcome after breast cancer in pregnancy. American Journal of Obstetrics & Gynecology. 1992;166(3):781-7.

Loibl S, Von Minckwitz G, Gwyn K, Ellis P, Blohmer JU, Schlegelberger B, et al. Breast carcinoma during pregnancy: international recommendations from an expert meeting. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2006;106(2):237-46.

Doll DC, Ringenberg QS, Yarbro JW. Antineoplastic agents and pregnancy. Semin Oncol. 1989;16(5):337-46.

Zagouri F, Psaltopoulou T, Dimitrakakis C, Bartsch R, Dimopoulos M-A. Challenges in managing breast cancer during pregnancy. Journal of thoracic disease. 2013;5(Suppl 1):S62.

Loibl S. New therapeutic options for breast cancer during pregnancy. Breast Care. 2008;3(3):171-6.

Berger JC, Clericuzio CL. Pierre Robin sequence associated with first trimester fetal tamoxifen exposure. American Journal of Medical Genetics Part A. 2008;146(16):2141- 4.

Bonnier P, Romain S, Dilhuydy JM, Bonichon F, Julien JP, Charpin C, et al. Influence of pregnancy on the outcome of breast cancer: A caseâ€control study. International journal of cancer. 1997;72(5):720-7.

Merkel DE. Pregnancy and breast cancer. Semin Surg Oncol. 1996;12(5):370-5.

Elledge RM, Ciocca DR, Langone G, McGuire WL. Estrogen receptor, progesterone receptor, and HERâ€2/neu protein in breast cancers from pregnant patients. Cancer. 1993;71(8):2499-506.

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Published

2020-12-16

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Section

Journal of Biomedical and Clinical Sciences